Neuro-Promotive Role of Quinic Acid against Rotenone Induced Rat Model of Parkinson’s Disease
Ravi Surya
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Arokiasamy Justin Thenmozhi
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India and Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.
Pandian Subasri
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Thamilarasan Manivasagam *
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Parkinson's disease (PD) is a common disorder that affects the movement of aged population, which is characterized by loss of dopaminergic neurons and depletion of dopamine due to oxidative stress, mitochondrial dysfunction, inflammation and apoptosis without any specific therapeutic implications. Quinic acid (QA) is a polyphenol with carboxylic acid present ubiquitously in plants and reported to have potent antioxidant activity. The present study shows the neuroprotective effect of quinic acid (QA) against rotenone induced rat model of PD. The behaviour tasks and estimation of neurochemical and biochemical indices and protein expression studies of α-synuclein and tyrosine hydroxylase were performed using standard procedures. QA significantly attenuated the adverse effects of rotenone by enhancing the levels of dopamine, GSH and activities of SOD, catalase and GPx and diminishing the levels of TBARS along with improved behavioural performance. Moreover, it reduced the expression of α-synuclein and enhanced the expression of tyrosine hydroxylase by its neuroprotective potential. However, further research is needed to study the protein expression of inflammatory and apoptotic markers to prove the anti-parkinsonic role of QA.
Keywords: Parkinson’s Disease, oxidative stress, reactive oxygen species, neuronal structure