Fabrication of Cadmium Sulphide Nanoparticles and Their Cytotoxicity Impacts
Ponpandi Ram Kumar
PG and Research Department of Chemistry, V.O. Chidambaram College, Tuticorin–628008, Tamil Nadu, India and Affiliated to Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli-627 012, Tamil Nadu, India.
Alagarsamy Mathavan *
PG and Research Department of Chemistry, V.O. Chidambaram College, Tuticorin–628008, Tamil Nadu, India and Affiliated to Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli-627 012, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
A typical semiconductor used in electronics is cadmium sulphide (CdS). In this study, CdS nanoparticles were sustainably synthesised using an extract from Plectranthus amboinicus. The cubic structure of the nanoparticles was confirmed through X-ray diffraction. While their nanoscale dimensions were evidenced by field emission scanning electron microscopy (FESEM). Additionally, organic compounds present on the surfaces were identified using Fourier-transform infrared spectroscopy (FTIR). According to UV-visible studies ranged from 200 to 800 nm, absorption peak at 476 nm confirms the formation of CdS nanoparticles. The 2.61 eV bandgap suggests longer wavelength transitions. Comparing to doxorubicin, anticancer tests showed a promising cytotoxicity against MCF-7 cells, with an IC50 of 122.015 µg/mL, suggesting the possibility of its use in anticancer therapy.
Keywords: Plectranthus amboinicus, MCF-7 cell line, CdS nanoparticles, surface plasmon resonance, cytotoxicity, MTT assay