UTTAR PRADESH JOURNAL OF ZOOLOGY

Benign prostate hyperplasia is a non-cancerous enlargement of prostate gland normally observed in older men over 60years of age. The present study investigated the effect of Mimosa pudica methanolic extract to evaluate different parameters like Sperm count, Urine volume, Prostate Somatic Index (PSI) and prostate histology on BPA induced BPH model of mouse. The animal groups (3 groups-control, BPA treated and Mimosa pudica methanolic extract treated) were treated for 10 days. In result it was found that the BPA treated group showed significant decrease in sperm count whereas, increase in Urine volume and PSI than the normal control group. After the extract treatment, the 3^rd experimental animal group showed significant increase in sperm count and decrease in urine volume and PSI as compared to the BPA treated group. The histological study showed reduction or shrinking enlarged glandular epithelium (GE) and infolding of GE reverse to normal state in the 3^rd group which seems to be increased in the BPA treated 2^nd group. The increased lumen of excretory duct (ED) due to reversal of infolding of GE is also seen in the 3^rd group. BPA is environmental endocrine disruptor which can bring decrease sperm count, increase urine volume and PSI and distort prostate tissue architecture. Mimosa pudica have certain phytochemicals which may have a very positive effect against Prostate enlargement and its negative effect on male reproductive system.