Evaluation of Anti-Arthritic Potential of Tribulus terrestris Seeds Extract in-vivo in Wistar Rats
Bolisetty Padmavathi
*
Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Lam, Chalapathi Nagar, Guntur-522034, India.
Mukiri Venkata Subbarao
Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Lam, Chalapathi Nagar, Guntur-522034, India.
Alluri Neha Saisri
Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Lam, Chalapathi Nagar, Guntur-522034, India.
Rama Rao Nadendla
Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Lam, Chalapathi Nagar, Guntur-522034, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: The main aim of present study is to evaluate the anti-arthritic potential of Tribulus terrestris seed extract in-vivo in Wistar rats.
Methods: The anti-arthritic activity of ethanolic extract of Tribulus terrestris seeds was evaluated by using three in vivo methods. In the formaldehyde-induced arthritis, the disease was induced by injecting 0.1 ml of formaldehyde into the hind paw. In the monosodium urate crystal model of anti-arthritis activity, the crystals were prepared by dissolving monosodium urate in boiling water, and then agitating at normal temperature. The carrageenan/kaolin model was used to induce arthritis by injecting 5% carrageenan/kaolin into the knee joint. The thickness of the paw was measured using a vernier caliper.
Results: When compared to the control group, the extract of Tribulus terrestris exhibits strong anti-arthritic effect. The activity increases with the dose concentration.
Conclusion: The Tribulus terrestris has anti-arthritic activity, and its efficacy rises in a dose-dependent way.
Keywords: Tribulus terrestris, maceration, ethanolic extract, anti-arthritic activity, formaldehyde, mono sodium urate crystals and kaolin/carrageenan