A Physiological Study to Compare the Effect of Catechin and Lovastatin on Obesity Through Histological Examination of the Liver in Albino Rats
Hala B. Thanoon Al-Bayati
*
Department Physiology, Biochemistry & Pharmacology, Faculty of Veterinary Medicine, University of Kufa, Iraq.
*Author to whom correspondence should be addressed.
Abstract
Obesity is a serious, intricate, long-term illness. Obesity is largely caused by a fatty diet. It is well established that a number of chronic illnesses, including “Non-Alcoholic Fatty Liver Disease” (NAFLD), are led to obesity. catechin as anti-obesity effects are very diverse. given orally for four weeks1.7 mg/kg. lovastatin 40mg/kg. Results show liver of control positive group rats’ Severe necrosis of hepatocytes lead to formed large spaces filled with severe hemorrhage and necrotic debris. Also, the fatty change as vacuoles. liver post catechin treatment group rats Mild fatty change appeared as vacuoles was observed. liver post lovastatin treatment group rats Mild fatty change as vacuoles with inflammatory cells infiltration as cluster. But normal hepatic tissue histology and the liver of the control negative group. Observe the configuration of acini and hexagonal lobules. We concluded through our current research that obesity, which is a metabolic disorder that we created by providing a high-fat diet, causes the deposition of fatty tissue in liver cells, as well as necrosis, bleeding, and destruction of liver cells. The use of catechin reduced the lesions in liver tissue and its effectiveness is at the same level as that of lovastatin, but rather better because it does not have the side effects of lovastatin.
Keywords: Catechin, lovastatin, liver, obesity