UTTAR PRADESH JOURNAL OF ZOOLOGY

Background: Diabetes mellitus, also known simply as diabetes, is a group of metabolic illnesses distinguished by raised blood glucose levels, either because cells do not respond to the insulin that is produced or from insufficient production of insulin. 

Aim: The present research aims to identify the effect of the varying amounts of cranberries (Rubus fruticosus) on biochemical alterations in hyperglycemic rats.

Materials and Methods: Twenty-four male Sprague Dawley rats were divided into two main groups. The first group consisted of group normal rats (number=6) as control (-). The second group (number = 18) received an intraperitoneal injection of streptozotocin at a dose of 75 milligrams per kilogram, and those with blood glucose concentrations above 250 milligrams per deciliters have been designated as diabetic. Rats in this main group have been separated into three subgroups: (1) the diabetic rats’ group as a control (+) (number=6) received a basal diet without any treatment; (2) the diabetic group (number=6) received a basal diet + 7% cranberries; & (3) the diabetic group (number=6) received a basal diet + 9% cranberries. Blood has been gathered following twenty-eight days, and serum has been extracted to assess levels, , HbA1c, liver enzymes, renal function, and blood lipids.

Results: Significant differences in glucose levels were observed among all groups. Group 4 illustrated the lowest value in glucose levels. Also, there are no statistical differences in AST and ALT between control (+) and groups 3 and 4. There is no statistical difference in low-density lipoprotein cholesterol (LDL-C) among control (+) and group (3). All groups 3 and 4 values showed statistical differences in urea when compared to the control (-) group.