Evaluating the Anticancer Properties of Musa acuminata colla Ethanolic Extract through In vitro Analysis
Anu Augustine
Department of Biotechnology, Sree Narayana Guru College, Coimbatore, Tamil Nadu, India.
Geethalakshmi Sundararaman *
Department of Biotechnology, RVS College of Arts and Science, Coimbatore, Tamil Nadu, India.
Prem Jose Vazhacharical
Department of Biotechnology, Mar Augusthinose College, Ramapuram, Kerala, India.
Syamkumar T.S.
Department of Biotechnology, Sree Narayana Guru College, Coimbatore, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
The study examined the possible anticancer properties of a colla pulp extract derived from Musa acuminata. It employed three different cancer cell lines, MDA-MB-231 (breast cancer), HCT-116 (colon cancer), and MG-63 (osteosarcoma). We evaluated the antiproliferative properties using the MTT test and identified the bioactive components through GC-MS analysis. The GC-MS analysis showed that the ethanol extract contained several compounds that could be useful in the fight against cancer. These compounds included palmitic acid, linoleic acid, 5-hydroxymethylfurfural, and 5-Methyl-2-ethylamino-2-thiazoline. The extract showed remarkable cytotoxicity against the cancer cell lines, with IC50 values of 250 µg/ml, 175 µg/ml, and 320 µg/ml for MDA-MB-231, HCT-116, and MG-63 cell lines, respectively. Finally, it was determined that banana pulp contains a significant number of phenolic compounds, provitamin A, and antioxidants. The present study suggests that bananas could have promising uses in the field of cancer research, treatment, and prevention.
Keywords: Breast cancer, colon cancer, osteosarcoma, anticancer, antiproliferation, bioactive compound, breast cancer