CO-INFECTION IN PYREXIA OF UNKNOWN ORIGIN AMONG PATIENTS ADMITTED AT A TERTIARY CARE HOSPITAL
ASMAT JAHAN
Department of Institute of Biosciences and Technology Shri Ramswaroop Memorial University, / Department of Microbiology, KGMU, Lucknow, India and Department of Microbiology, King George’s Medical University, Lucknow, India.
PRACHI BHARGAVA *
Department of Institute of Biosciences and Technology Shri Ramswaroop Memorial University, / Department of Microbiology, KGMU, Lucknow, India.
RAJ KUMAR KALYAN
Department of Microbiology, King George’s Medical University, Lucknow, India.
SANJEEV KUMAR VERMA
Department of Pediatric, KGMU, Lucknow, India.
KAMLESH KUMAR GUPTA
Department of Medicine, KGMU, Lucknow, India.
RENU KUMARI
Department of Microbiology, King George’s Medical University, Lucknow, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Pyrexia of unknown origin has become a major problem in developing countries including India. In tropical region during monsoon and post-monsoon period there are high chances of dual infection and cross reactivity. The objective of the present study was to find incidence of co-infection among patients with Pyrexia of unknown origin.
Methods: This was a hospital based prospective study conducted over a period of One year (January to December) in 2018 in the department of microbiology. A total of 80 PUO cases were collected from different wards of King George’s Medical University, Lucknow, UP, India. Serological methods were applied for diagnosis of infection.
Results: In this study a total of 80 pyrexia cases were studied, of those 80 pyrexia cases, 27(33.75%) of pyrexia cases were detected due to infection of which co infection contributed to 7/80(8.75%) and single infection were detected in 20(25%). The most common co-infection was Leptospirosis and Scrub typhus reported in 3 patients while Leptospirosis and Malaria was observed in one patient.
Conclusion: This study showed presence of dual infection as a cause of PUO. Serology-based investigations played a vital role in establishing diagnosis.
Keywords: PUO, ELISA, scrub typhus, leptospirosis, co-infection