UTTAR PRADESH JOURNAL OF ZOOLOGY

Heterocyclic bearing nitrogen constitutes the core structure of number of pharmacological and biologically active interesting compounds. Heterocyclic compounds show vital role in the field of pharmaceuticals. In the present investigation treatment of diseases possess challenging problems due to emerging infectious disease and also due to increased  multi drug resistance pathogens in spite of commercially available antibiotics and drugs search for novel compound with theoretical values are mandatory Pyrazole was screened for anti-bacterial activity against shigella flexneri, E. coli, Pseudomonas aeruginosa, Pseudomonas fluorescence respectively. The anti-fungal activity of three fungal namely as Aspergillus niger, Aspergillus flavus and Odium caricae were evaluated and it was found to be pyrazole was found to be effectively. The anti-inflammatory performance of pyrazole compound was tested with formalin induced paw edema test activity by oral administration at a dose level of 100mg/kg compared to reference drug paracetamol. The potential analgesic activity of pyrazole using animal model was carried out with oral administration of pyrazole 100mg/kg of body weight. The anti-pyretic activity of pyrazole was determined on yeast induced pyrexia in albino mice. FTIR is an important tool analyzed to analysis functional group modification of pyrazole and its derivatives. In my research findings, strongly recommended for pyrazole as best drug to the enzyme and greater the number of sites occupied, the more effective the drug is likely to be in inhibiting the action of the enzymes.